The Toll receptor family and microbial recognition

被引：523

作者：

Medzhitov, R ^{[1
]}

Janeway, C ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(00)01845-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.

引用

页码：452 / 456

页数：5

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