Host regulation of glial markers in intrastriatal grafts of conditionally immortalized neural stem cell lines

被引：29

作者：

Lundberg, C

Bjorklund, A

机构：

[1] Department of Medical Cell Research, University of Lund, 223 62 Lund

来源：

NEUROREPORT | 1996年 / 7卷 / 04期

关键词：

temperature-sensitive; SV40 large T-antigen; stem cell lines; intracerebral transplantation; lesion-induced astrogliosis; differentiation;

D O I：

10.1097/00001756-199603220-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AFTER transplantation into the adult CNS the immortalized neural stem cell lines ST14A and HiB5 differentiate preferentially into glia-like cells. After lesions of the host brain, which activate resting glial populations, the grafted cells responded with up-regulation of glial markers and a change in morphology towards a reactive state. The protein expression followed the same pattern as in the host glial population. The results show that the astrocytes formed by the grafted neural stem cells become functionally integrated in the host brain and that they may take an active part in the reactive gliosis caused by brain damage.

引用

收藏

页码：847 / 852

页数：6

相关论文

共 28 条

[1] AN OLIGODENDROCYTE PRECURSOR CELL-LINE FROM RAT OPTIC-NERVE [J].

ALMAZAN, G ;

MCKAY, R .

BRAIN RESEARCH, 1992, 579 (02) :234-245

[2] THE KINETICS AND MORPHOLOGICAL-CHARACTERISTICS OF THE MACROPHAGE MICROGLIAL RESPONSE TO KAINIC ACID-INDUCED NEURONAL DEGENERATION [J].

ANDERSSON, PB ;

PERRY, VH ;

GORDON, S .

NEUROSCIENCE, 1991, 42 (01) :201-214

[3] NEURAL-TARGETED GENE-THERAPY FOR RODENT AND PRIMATE HEMIPARKINSONISM [J].

ANTON, R ;

KORDOWER, JH ;

MAIDMENT, NT ;

MANASTER, JS ;

KANE, DJ ;

RABIZADEH, S ;

SCHUELLER, SB ;

YANG, J ;

RABIZADEH, S ;

EDWARDS, RH ;

MARKHAM, CH ;

BREDESEN, DE .

EXPERIMENTAL NEUROLOGY, 1994, 127 (02) :207-218

[4] COEXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN AND VIMENTIN IN REACTIVE ASTROCYTES FOLLOWING BRAIN INJURY IN RATS [J].

CALVO, JL ;

CARBONELL, AL ;

BOYA, J .

BRAIN RESEARCH, 1991, 566 (1-2) :333-336

[5] DIFFERENTIAL REGULATION OF NEUROPEPTIDE MESSENGER-RNA EXPRESSION IN INTRASTRIATAL STRIATAL TRANSPLANTS BY HOST DOPAMINERGIC AFFERENTS [J].

CAMPBELL, K ;

WICTORIN, K ;

BJORKLUND, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10489-10493

[6] A SHORT-TERM ANALYSIS OF THE BEHAVIOR OF CONDITIONALLY IMMORTALIZED NEURONAL PROGENITORS AND PRIMARY NEUROEPITHELIAL CELLS IMPLANTED INTO THE FETAL-RAT BRAIN [J].

CATTANEO, E ;

MAGRASSI, L ;

BUTTI, G ;

SANTI, L ;

GIAVAZZI, A ;

PEZZOTTA, S .

DEVELOPMENTAL BRAIN RESEARCH, 1994, 83 (02) :197-208

[7]

CATTANEO E, 1993, SOC NEUR ABSTR, V107, P6

[8]

CHANG HW, 1994, NEUROSCIENCE, V62, P425

[9] GLIAL CHANGES FOLLOWING AN EXCITOTOXIC LESION IN THE CNS .2. ASTROCYTES [J].

DUSART, I ;

MARTY, S ;

PESCHANSKI, M .

NEUROSCIENCE, 1991, 45 (03) :541-549

[10] ASTROGLIAL RESPONSE IN THE EXCITOTOXICALLY LESIONED NEOSTRIATUM AND ITS PROJECTION AREAS IN THE RAT [J].

ISACSON, O ;

FISCHER, W ;

WICTORIN, K ;

DAWBARN, D ;

BJORKLUND, A .

NEUROSCIENCE, 1987, 20 (03) :1043-1056