Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions

被引:185
作者
Bauer, Wolfgang-Andreas C. [1 ]
Fischlechner, Martin
Abell, Chris
Huck, Wilhelm T. S. [1 ,2 ]
机构
[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England
[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
基金
英国工程与自然科学研究理事会;
关键词
REACTIVE POLYMER-COATINGS; MULTIPLE EMULSIONS; HYDROPHOBIC RECOVERY; MICROFLUIDIC DEVICES; SURFACE MODIFICATION; CAPILLARY-ELECTROPHORESIS; NANOLITER PLUGS; GRAFT-POLYMERIZATION; DELIVERY SYSTEMS; PLASMA TREATMENT;
D O I
10.1039/c004046k
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Here we present a novel surface modification method based on the sequential layer-by-layer deposition of polyelectrolytes yielding hydrophilic microchannels in PDMS-based microfluidic devices. The coatings are long-term stable and allow for the generation of monodisperse oil-in-water microdroplets even several months after the channel surface treatment. Due to the robustness of the polyelectrolyte multilayers ultra-high flow rates can be applied, making high-throughput droplet formation in the jetting mode possible. Furthermore, we successfully used our method to selectively modify the surface properties in certain areas of assembled microchannels. The resulting partially hydrophilic, partially hydrophobic microfluidic devices allow for the production of monodisperse water-in-oil-in-water double emulsions.
引用
收藏
页码:1814 / 1819
页数:6
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