Oral prednisolone metasulphobenzoate in the treatment of active ulcerative colitis

被引:14
作者
Cameron, EAB
Binnie, JAH
Balan, K
Skerratt, SA
Swift, A
Solanki, C
Middleton, SJ
机构
[1] Addenbrookes Hosp, Dept Gastroenterol, Cambridge CB2 2QQ, England
[2] Addenbrookes Hosp, Dept Nucl Med, Cambridge CB2 2QQ, England
关键词
colitis; ulcerative; glucocorticoids; synthetic; radionuclide imaging;
D O I
10.1080/00365520310001914
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Corticosteroids are one of the mainstays of treatment for active ulcerative colitis, but they are associated with numerous side effects. The sparingly absorbed corticosteroid prednisolone metasulphobenzoate is used topically in the treatment of distal disease. A targeted-release oral preparation (Predocol) has been developed to allow delivery of this drug to the whole colon. We have studied the effect of oral Predocol on inflammation as measured by Tc-99(m)-HMPAO leucocyte scintigraphy in patients with symptomatic and sigmoidoscopic relapse of known extensive ulcerative colitis. Methods: Fourteen patients were recruited and received Predocol 47.1 mg twice daily, 8 for 7 days and 6 for 14 days. Scintigraphy was performed prior to and at the end of treatment. Each segment of colon was graded (0-4) and individual scores summed to give a total scintigraphic score. Results: Total scintigraphic score improved by a mean of 2.5 (P = 0.027). Mean individual scores improved in the rectum by 0.7 (P = 0.038) and in the descending colon by 0.8 (P = 0.033). Conclusions: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.
引用
收藏
页码:535 / 537
页数:3
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