Multidrug Resistance Protein 1 (MRP1, ABCC1), a "Multitasking" ATP-binding Cassette (ABC) Transporter

被引：285

作者：

Cole, Susan P. C. ^{[1
,2
]}

机构：

[1] Queens Univ, Dept Pathol & Mol Med, Kingston, ON K7L 3N6, Canada

[2] Queens Univ, Div Canc Biol & Genet, Kingston, ON K7L 3N6, Canada

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2014年 / 289卷 / 45期

基金：

加拿大健康研究院;

关键词：

ORGANIC ANION TRANSPORTER; ANTHRACYCLINE-INDUCED CARDIOTOXICITY; CHARGED AMINO-ACIDS; P-GLYCOPROTEIN; LEUKOTRIENE C-4; SUBSTRATE RECOGNITION; GLUTATHIONE DISULFIDE; INCREASED SENSITIVITY; MUTATIONAL ANALYSIS; LIPID-PEROXIDATION;

D O I：

10.1074/jbc.R114.609248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing body of evidence indicates that additional lipid-derived mediators are also substrates of this transporter. As such, MRP1 is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.

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收藏

页码：30880 / 30888

页数：9

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