Synthesis of enantiopure 3-chlorostyrene oxide via an asymmetric epoxidation-hydrolytic kinetic resolution sequence

被引：78

作者：

Brandes, BD ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0957-4166(97)00568-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Chlorostyrene oxide was prepared in >99% ee employing the (salen)Co-catalyzed hydrolytic kinetic resolution (HKR) reaction. The HKR was performed successfully on both racemic and enantiomerically enriched epoxides, the latter was obtained via (salen)Mn-catalyzed asymmetric epoxidation reactions. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：3927 / 3933

页数：7

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