Cardiovascular diseases:: new insights from knockout mice

被引：13

作者：

D'Orléans-Juste, P ^{[1
]}

Honoré, JC ^{[1
]}

Carrier, E ^{[1
]}

Labonté, J ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Pharmacol, Sch Med, Inst Pharmacol, N Sherbrooke, PQ J1H 5N4, Canada

来源：

CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 02期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S1471-4892(03)00017-1

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Knockout (KO) mice models have generated a wealth of new information on the developmental and physiopathological roles of several hormones and their receptors. In these mice, KO of a specific gene can be lethal at embryonic stages or during early adulthood. Furthermore, in conditions of non-lethality, KO mice may compensate for the repression of a particular protein expression. As a result of these two aspects, various phenotypic expressions occur in KO mice models for several peptides and their respective receptors, as well as for the enzymes involved in their processing.

引用

页码：181 / 185

页数：5

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