Enterobacterial adhesins and the case for studying SNPs in bacteria

被引：35

作者：

Weissman, SJ

Moseley, SL

Dykhuizen, DE

Sokurenko, EV

机构：

[1] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[2] Childrens Hosp & Reg Med Ctr, Div Infect Dis, Seattle, WA 98105 USA

[3] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0966-842X(03)00010-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single-nucleotide polymorphisms (SNPs) in structural genes can have a dramatic effect on the biology of whole organisms, from bacteria and viruses to mammals. Here, we underscore the importance of SNPs in bacterial genes that contribute to the ability of pathogens to cause disease. SNPs that confer an adaptive advantage for bacterial pathogens have been discovered in the genes encoding the FimH and Dr adhesins of Escherichia coli and, most recently, Salmonella enterica sv. Typhimurium FimH.

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页码：115 / 117

页数：3

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