The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

被引：639

作者：

Gibellini, Federica ^{[1
]}

Smith, Terry K. ^{[1
]}

机构：

[1] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

IUBMB LIFE | 2010年 / 62卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Kennedy pathway; ethanolamine; choline; CDP-ethanolamine; CDP-choline; CTP-PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASE; EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS; CDP-ETHANOLAMINE PATHWAY; SACCHAROMYCES-CEREVISIAE; CHOLINE KINASE; RAT-LIVER; TRYPANOSOMA-BRUCEI; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; SPHINGOLIPID METABOLISM; MOLECULAR DISSECTION;

D O I：

10.1002/iub.337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010

引用

页码：414 / 428

页数：15

共 98 条

[1] Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases
Alberge, Blandine
Gannoun-Zaki, Leila
Bascunana, Celine
Van Ba, Christophe Tran
Vial, Henri
Cerdan, Rachel
[J]. BIOCHEMICAL JOURNAL, 2010, 425 : 149 - 158
[2] In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism
Ancelin, ML
Calas, M
Bonhoure, A
Herbute, S
Vial, HJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (08) : 2598 - 2605
[3] Structure and function of choline kinase isoforms in mammalian cells
Aoyama, C
Liao, HN
Ishidate, K
[J]. PROGRESS IN LIPID RESEARCH, 2004, 43 (03) : 266 - 281
[4] Expression and characterization of the active molecular forms of choline/ethanolamine kinase-α and -β in mouse tissues, including carbon tetrachloride-induced liver
Aoyama, C
Ohtani, A
Ishidate, K
[J]. BIOCHEMICAL JOURNAL, 2002, 363 (03) : 777 - 784
[5] Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis:: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)
Bakovic, Marica
Fullerton, Morgan D.
Michel, Vera
[J]. BIOCHEMISTRY AND CELL BIOLOGY, 2007, 85 (03) : 283 - 300
[6] Roles of phosphatidylethanolamine and of its several biosynthetic pathways in Saccharomyces cerevisiae
Birner, R
Bürgermeister, M
Schneiter, R
Daum, G
[J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) : 997 - 1007
[7] Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver
Bladergroen, BA
Houweling, M
Geelen, MJH
van Golde, LMG
[J]. BIOCHEMICAL JOURNAL, 1999, 343 : 107 - 114
[8] The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species
Bleijerveld, Onno B.
Brouwers, Jos F. H. M.
Vaandrager, Arie B.
Helms, J. Bernd
Houweling, Martin
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (39) : 28362 - 28372
[9] To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology
Bogdanov, Mikhail
Xie, Jun
Heacock, Phil
Dowhan, William
[J]. JOURNAL OF CELL BIOLOGY, 2008, 182 (05) : 925 - 935
[10] THE CYTIDYLYLTRANSFERASE SUPERFAMILY - IDENTIFICATION OF THE NUCLEOTIDE-BINDING SITE AND FOLD PREDICTION
BORK, P
HOLM, L
KOONIN, EV
SANDER, C
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1995, 22 (03): : 259 - 266

← 1 2 3 4 5 6 7 8 9 10 →