Type I interferons and T helper development

被引：87

作者：

Farrar, JD ^{[1
]}

Murphy, KM

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Howard Hughes Med Inst, Ctr Immunol, St Louis, MO 63110 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(00)01710-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I interferons (IFN-ls) activate Stat4 and promote Th1 development in human, but not mouse, CD4(+) T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine ann human Stat2 explains the ability of human, but not mouse, CD4(+) T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

引用

页码：484 / 489

页数：6

共 50 条

[1] INTERLEUKIN-12 INDUCES TYROSINE PHOSPHORYLATION AND ACTIVATION OF STAT4 IN HUMAN-LYMPHOCYTES
BACON, CM
PETRICOIN, EF
ORTALDO, JR
REES, RC
LARNER, AC
JOHNSTON, JA
O'SHEA, JJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) : 7307 - 7311
[2] Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection
Barillas-Mury, C
Han, YS
Seeley, D
Kafatos, FC
[J]. EMBO JOURNAL, 1999, 18 (04) : 959 - 967
[3] INTERFERON-ALPHA INCREASES THE FREQUENCY OF INTERFERON-GAMMA-PRODUCING HUMAN CD4+ T-CELLS
BRINKMANN, V
GEIGER, T
ALKAN, S
HEUSSER, CH
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) : 1655 - 1663
[4] Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon γ production from CD4+ versus CD8+ T cells
Carter, LL
Murphy, KM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) : 1355 - 1360
[5] Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
Cella, M
Jarrossay, D
Facchetti, F
Alebardi, O
Nakajima, H
Lanzavecchia, A
Colonna, M
[J]. NATURE MEDICINE, 1999, 5 (08) : 919 - 923
[6] On the asymptotic behavior of the independence number of a random (n,n)-tree
Cho, JH
Palmer, EM
[J]. GRAPHS AND COMBINATORICS, 1996, 12 (01) : 1 - 8
[7] Two roads diverged:: Interferon α/β- and interleukin 12-mediated pathways in promoting T cell interferon γ responses during viral infection
Cousens, LP
Peterson, R
Hsu, S
Dorner, A
Altman, JD
Ahmed, R
Biron, CA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) : 1315 - 1327
[8] De Maeyer E, 1998, Int Rev Immunol, V17, P53, DOI 10.3109/08830189809084487
[9] Type I interferons: expression and signalization
Doly, J
Civas, A
Navarro, S
Uze, G
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 1998, 54 (10) : 1109 - 1121
[10] Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells
Dumler, I
Kopmann, A
Wagner, K
Mayboroda, OA
Jerke, U
Dietz, R
Haller, H
Gulba, DC
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) : 24059 - 24065

← 1 2 3 4 5 →