Modulation of upper extremity motoneurone excitability following noxious finger tip stimulation in man: a study with transcranial magnetic stimulation

被引：42

作者：

Kofler, M

Glocker, FX

Leis, AA

Seifert, C

Wissel, J

Kronenberg, MF

Fuhr, P

机构：

[1] Univ Innsbruck Hosp, Dept Neurol, A-6020 Innsbruck, Austria

[2] Univ Hosp Freiburg, Dept Neurol, Freiburg, Germany

[3] Univ Mississippi, Dept Neurol, Jackson, MS 39216 USA

[4] Univ Basel Hosp, Dept Neurol, CH-4031 Basel, Switzerland

来源：

NEUROSCIENCE LETTERS | 1998年 / 246卷 / 02期

关键词：

cutaneous stimulation; transcranial magnetic stimulation; motor evoked potential; protective reflex; inhibition; facilitation; pain; human;

D O I：

10.1016/S0304-3940(98)00243-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Little is known about nociceptive reflex mechanisms in the upper limb in humans. To investigate nociceptive effects on spinal motoneurone excitability, a conditioning noxious stimulus was applied to the index finger of five healthy subjects. Motor evoked potentials (MEPs) following contralateral transcranial magnetic stimulation (TMS) were recorded from thenar eminence (TE) and biceps brachii (BB) muscles ipsilateral to finger stimulation. TMS was randomly applied alone or combined with preceding finger stimulation at an interstimulus interval of 100 ms. MEP amplitudes were profoundly suppressed in TE and augmented in BE. We conclude that nociception produces a differential effect on different spinal motoneurone pools, which may be part of a complex protective reflex mechanism in the upper limb of humans. (C) 1998 Published by Elsevier Science Ireland Ltd.

引用

页码：97 / 100

页数：4

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