Getting a grip on strangles: Recent progress towards improved diagnostics and vaccines

被引：59

作者：

Waller, Andrew S.

Jolley, Keith A.

机构：

[1] Anim Hlth Trust, Ctr Prevent Med, Newmarket CB8 7UU, Suffolk, England

[2] Univ Oxford, Dept Zool, Oxford OX1 3SY, England

来源：

VETERINARY JOURNAL | 2007年 / 173卷 / 03期

关键词：

strangles; diagnosis; vaccines; subtyping; virulence;

D O I：

10.1016/j.tvjl.2006.05.011

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

'Strangles', caused by infection with the bacterium Streptococcus equi, remains one of the most commonly diagnosed and important infectious diseases of horses world-wide. This review discusses the diagnosis and pathogenesis of strangles with particular attention to the significance of persistent infections in disease transmission and the rapid progress now being made towards the development of effective preventative vaccines. It is now possible combine recent sequence data from the N-terminal region of the SeM protein and reassign the SeM alleles using the on-line database http://pubmist.org/szooepidemicus/seM/. Hypotheses concerning the origin of this variation and the potential for its exploitation for the epidemiological analysis of outbreaks are proposed. Advances in understanding of the molecular evolution of S. equi highlight the role played by phage-mediated acquisition of virulence factors and suggest new avenues for prophylactic intervention. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：492 / 501

页数：10

共 58 条

[1] Dissemination of the superantigen encoding genes seeL, seeM, szeL and szeM in Streptococcus equi subsp equi and Streptococcus equi subsp zooepidemicus [J].