Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment

被引：300

作者：

Andrews, Jonathan P. ^{[1
]}

Marttala, Jaana ^{[1
]}

Macarak, Edward ^{[1
,2
]}

Rosenbloom, Joel ^{[1
,2
]}

Uitto, Jouni ^{[1
,3
]}

机构：

[1] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Joan & Joel Rosenbloom Res Ctr Fibrot Dis, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USA

[3] Thomas Jefferson Univ, Jefferson Inst Mol Med, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USA

来源：

MATRIX BIOLOGY | 2016年 / 51卷

关键词：

Fibrotic disease; Inflammation; Keloid; Collagen; TGF-beta; Wound healing; ENDOTHELIAL GROWTH-FACTOR; IMIQUIMOD 5-PERCENT CREAM; EXTRA DOMAIN-A; TGF-BETA; MATRIX METALLOPROTEINASES; GENE-EXPRESSION; CELLULAR FIBRONECTIN; SUSCEPTIBILITY LOCI; HYPERTROPHIC SCARS; FIBROBLAST GROWTH;

D O I：

10.1016/j.matbio.2016.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix (ECM) components, particularly collagen, result from excessive expression of growth factors and cytokines. The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals. Several treatment methods for keloids exist, including the combination therapy of surgical excision followed by intralesional steroid therapy, however, they have high recurrence rate regardless of the current treatment method. Improved understanding of the pathomechanisms leading to keloid formation will hopefully identify pathways that serve as specific targets to improve therapy for this devastating, currently intractable, disorder. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：37 / 46

页数：10

共 97 条

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