Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus

被引：14

作者：

Coffin, SE

Offit, PA

机构：

[1] Childrens Hosp, Div Infect Dis & Immunol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[3] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 04期

关键词：

D O I：

10.1128/JVI.72.4.3479-3483.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.

引用

收藏

页码：3479 / 3483

页数：5

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