Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide

被引：23

作者：

de Requena, Daniel Gonzalez ^{[1
]}

Calcagno, Andrea ^{[1
]}

Bonora, Stefano ^{[1
]}

Ladetto, Laura ^{[1
]}

D'Avolio, Antonio ^{[1
]}

Sciandra, Mauro ^{[1
]}

Siccardi, Marco ^{[1
]}

Bargiacchi, Olivia ^{[1
]}

Sinicco, Alessandro ^{[1
]}

Di Perri, Giovanni ^{[1
]}

机构：

[1] Univ Turin, Dept Infect Dis, Turin, Italy

来源：

AIDS | 2006年 / 20卷 / 15期

关键词：

D O I：

10.1097/01.aids.0000247121.19951.fa

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.

引用

页码：1977 / 1979

页数：3

共 7 条

[1]

*BOEHR ING PHARM I, 2005, TIPR ANT DRUGS ADV C

[2] Lack of enzyme-inducing effect of rifampicin on the pharmacokinetics of enfuvirtide [J].