Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

被引：88

作者：

Olivera, Ana ^{[1
]}

Eisner, Christoph ^{[2
]}

Kitamura, Yoshiaki ^{[1
]}

Dillahunt, Sandra ^{[1
]}

Allende, Laura ^{[3
]}

Tuymetova, Galina ^{[3
]}

Watford, Wendy ^{[4
]}

Meylan, Francoise ^{[5
]}

Diesner, Susanne C. ^{[1
]}

Li, Lingli ^{[2
]}

Schnermann, Jurgen ^{[2
]}

Proia, Richard L. ^{[3
]}

Rivera, Juan ^{[1
]}

机构：

[1] Natl Inst Arthrit & Musculoskeletal & Skin Dis NI, Immunogenet Mol Lab, NIH, Bethesda, MD USA

[2] NIDDK, Kidney Dis Branch, NIH, Bethesda, MD USA

[3] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD USA

[4] NIAMS, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD USA

[5] NIAMS, Autoimmun Branch, NIH, Bethesda, MD USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 05期

基金：

美国国家科学基金会;

关键词：

MAST-CELL DEGRANULATION; FC-EPSILON-RI; VASCULAR-PERMEABILITY; SYSTEMIC-ANAPHYLAXIS; S1P(1) RECEPTOR; GAMMA RIII; HISTAMINE; ACTIVATION; EXPRESSION; IMMUNE;

D O I：

10.1172/JCI40659

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sphingosine kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (SIP), a ligand for a family of G protein-coupled receptors (S1PR1-S1PR5) with important functions in the vascular and immune systems. Here we explore the role of these kinases and receptors in recovery from anaphylaxis in mice. We found that Sphk2(-/-) mice had a rapid recovery from anaphylaxis. In contrast, Sphk1(-/-) mice showed poor recovery from anaphylaxis and delayed histamine clearance. Injection of SIP into Sphk1(-/-) mice increased histamine clearance and promoted recovery from anaphylaxis. Adoptive cell transfer experiments demonstrated that SphK1 activity was required in both the hematopoietic and nonhematopoietic compartments for recovery from anaphylaxis. Mice lacking the SW receptor S1PR2 also showed a delay in plasma histamine clearance and a poor recovery from anaphylaxis. However, SW did not promote the recovery of S1pr2(-/-) mice from anaphylaxis, whereas S1pr2(+/-) mice showed partial recovery. Unlike Sphk2(-/-) mice, Sphk1(-/-) and S1pr2(-/-) mice had severe hypotension during anaphylaxis. Thus, SphK1-produced S1P regulates blood pressure, histamine clearance, and recovery from anaphylaxis in a manner that involves S1PR2. This suggests that specific S1PR2 agonists may serve to counteract the vasodilation associated with anaphylactic shock.

引用

页码：1429 / 1440

页数：12

共 61 条

[1] CATABOLISM OF HISTAMINE IN THE ISOLATED GLOMERULI AND TUBULES OF THE RAT-KIDNEY [J].

ABBOUD, HE .

KIDNEY INTERNATIONAL, 1983, 24 (04) :534-541

[2]

Akdis Cezmi A., 2008, V94, P67, DOI 10.1159/000154858

[3] S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues [J].

Allende, Maria L. ;

Zhou, Dapeng ;

Kalkofen, Danielle N. ;

Benhamed, Sonia ;

Tuymetova, Galina ;

Borowski, Christine ;

Bendelac, Albert ;

Proia, Richard L. .

FASEB JOURNAL, 2008, 22 (01) :307-315

[4] Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720 [J].

Allende, ML ;

Sasaki, T ;

Kawai, H ;

Olivera, A ;

Mi, YD ;

van Echten-Deckert, G ;

Hajdu, R ;

Rosenbach, M ;

Keohane, CA ;

Mandala, S ;

Spiegel, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52487-52492

[5] Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma [J].

Ammit, AJ ;

Hastie, AT ;

Edsall, LC ;

Hoffman, RK ;

Amrani, Y ;

Krymskaya, VP ;

Kane, SA ;

Peters, SP ;

Penn, RB ;

Spiegel, S ;

Panettieri, RA .

FASEB JOURNAL, 2001, 15 (07) :1212-1214

[6] The ins and outs of IgE-dependent mast-cell exocytosis [J].

Blank, U ;

Rivera, J .

TRENDS IN IMMUNOLOGY, 2004, 25 (05) :266-273

[7] Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase [J].

Bolz, SS ;

Vogel, L ;

Sollinger, D ;

Derwand, R ;

Boer, C ;

Pitson, SM ;

Spiegel, S ;

Pohl, U .

CIRCULATION, 2003, 108 (03) :342-347

[8] Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice [J].

Camerer, Eric ;

Regard, Jean B. ;

Cornelissen, Ivo ;

Srinivasan, Yoga ;

Duong, Daniel N. ;

Palmer, Daniel ;

Pham, Trung H. ;

Wong, Jinny S. ;

Pappu, Rajita ;

Coughlin, Shaun R. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (07) :1871-1879

[9]

Choi OH, 1996, NATURE, V380, P634

[10] Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis [J].

Chrusch, C ;

Sharma, S ;

Unruh, H ;

Bautista, E ;

Duke, K ;

Becker, A ;

Kepron, W ;

Mink, SN .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (04) :1142-1149

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