T lymphocyte differentiation in the periphery

被引：88

作者：

Murphy, KM ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(98)80253-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4(+) T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in The development, data regarding IFN-gamma gene expression and clarification of the action of the new cytokine IL-18. (C) Current Biology Ltd ISSN 0952-7915.

引用

页码：226 / 232

页数：7

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