Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor type III polyketide synthases

被引：31

作者：

Gruschow, Sabine

Buchholz, Tonia J.

Seufert, Wolfgang

Dordick, Jonathan S.

Sherman, David H.

机构：

[1] Univ Michigan, Chem Biol Program, Dept Med Chem, Life Sci Inst, Ann Arbor, MI 48109 USA

[2] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 08期

关键词：

acyl carrier protein; biosynthesis; natural products; polyketides; pyrones;

D O I：

10.1002/cbic.200700026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Protein partners. We report the biochemical characterization of two type III polyketide synthases (PKS) from Streptomyces coelicolor. Remarkably, germicidin synthase (Gcs)/SCO7221 was able to utilize both acyl-CoA and acyl-ACP as starter units for the production of pyrone containing compounds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：863 / 868

页数：6

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