Lipids and essential fatty acids in patients presenting with self-harm

被引:56
作者
Garland, Malcolm R.
Hallahan, Brian
McNamara, Mairead
Carney, Philip A.
Grimes, Helen
Hibbeln, Joseph R.
Harkin, Andrew
Conroy, Ronan M.
机构
[1] Natl Univ Ireland Univ Coll Galway, Galway Univ Hosp, Dept Adult Psychiat, Galway, Ireland
[2] Natl Univ Ireland Univ Coll Galway, Inst Clin Sci, Galway, Ireland
[3] Natl Univ Ireland Univ Coll Galway, Dept Expt Pharmacol, Galway, Ireland
[4] Galway Univ Hosp, Dept Clin Biochem, Galway, Ireland
[5] NIAAA, Lab Membrane Biochem & Biophys, Rockville, MD 20852 USA
[6] Royal Coll Surgeons Ireland, Dept Epidemiol & Biostat, Dublin 2, Ireland
关键词
SERUM-CHOLESTEROL LEVELS; SEROTONIN; DEPRESSION; SUICIDE; BRAIN; CONSUMPTION; REDUCTION; MORTALITY; VIOLENT;
D O I
10.1192/bjp.bp.105.019562
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Low cholesterol has been reliably demonstrated in people who self-harm. Aims To determine whether people who self-harm also have low levels of essential fatty acids (EFAs) and to examine associations between the EFAs and serotonergic function. Method Depression, impulsivity and suicidal intent were measured in patients with self-harm (n=40) and matched controls, together with plasma lipids and EFAs. Platelet serotonergic studies were carried out in a subgroup (n=27). Results Patients with self-harm had significantly more pathology on all psychometric measures, lower mean total cholesterol levels (4.18 (s. d. = 0.93) v. 4.87 (s.d.=0.83) mmol/l, P=0.003) and lower mean total EFA levels (89.5 (15.6) v. 103.7 (17.1) mu g/ml, P=0.0001) than controls after adjustment for confounding variables. Total n-3 and n-6 EFA levels were also significantly lower. Impulsivity and depression scores were significantly inversely correlated with both n-6 EFAs and n-3 EFAs, but were not associated with total or low-density lipoprotein cholesterol levels. Platelet serotonergic measures did not differ between groups, and were not related to psychobiological measures. Conclusions Lower plasma EFA levels combined with low cholesterol concentrations were associated with self-harm as well as impulsivity and affect. This was not related to platelet serotonergic measures. Declaration of interest None.
引用
收藏
页码:112 / 117
页数:6
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