Regiospecific reduction of 5-benzylidene-2,4-thiazolidinediones and 4-oxo-2-thiazolidinethiones using lithium borohydride in pyridine and tetrahydrofuran

被引：61

作者：

Giles, RG ^{[1
]}

Lewis, NJ ^{[1
]}

Quick, JK ^{[1
]}

Sasse, MJ ^{[1
]}

Urquhart, MWJ ^{[1
]}

Youssef, L ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 26期

关键词：

regiospecific; conjugate reduction; lithium borohydride; benzylthiazolidinediones;

D O I：

10.1016/S0040-4020(00)00361-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel regiospecific and general reduction of 5-benzylidene-2,4-thiazolidinediones and 5-benzylidene-4-oxo-2-thiazolidinethiones to the corresponding 5-benzyl derivatives has been accomplished using lithium borohydride in pyridine and tetrahydrofuran. Sodium borohydride and lithium chloride can also be used under these conditions, which represents a cheaper alternative to lithium borohydride. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4531 / 4537

页数：7

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