Temozolomide in patients with high grade gliomas

被引：23

作者：

Brandes, AA ^{[1
]}

Pasetto, LM ^{[1
]}

Vastola, F ^{[1
]}

Monfardini, S ^{[1
]}

机构：

[1] Univ Padua, Azienda Osped, Div Oncol Med Direzione, I-35100 Padua, Italy

来源：

ONCOLOGY | 2000年 / 59卷 / 03期

关键词：

temozolomide; chemotherapy; brain tumors;

D O I：

10.1159/000012158

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of central nervous system neoplasias ranges from 3.8 to 5.1 cases per 100,000 inhabitants. First-line treatment of brain tumors consists of surgery associated with radiotherapy, and followed or not by chemotherapy. When used as an adjuvant therapy after surgery and radiotherapy, chemotherapy prolongs the time to progression and the median survival time. At relapse, chemotherapy is the common therapeutic approach. In recent years, new drugs for the treatment of brain tumors have been tested, and some of them, such as temozolomide, are very promising. Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：181 / 186

页数：6

共 48 条

[1]

BAKER SD, 1997, ASCO, V16, P214

[2]

BALANICH M, 1996, CANCER CHEMOTH PHARM, V37, P547

[3]

Balis F., 1995, P AN M AM SOC CLIN, V14, P461

[4]

Bobola MS, 1996, CLIN CANCER RES, V2, P735

[5] CANCER STATISTICS, 1993 [J].

BORING, CC ;

SQUIRES, TS ;

TONG, T .

CA-A CANCER JOURNAL FOR CLINICIANS, 1993, 43 (01) :7-26

[6] POTENTIATION OF TEMOZOLOMIDE-INDUCED CYTOTOXICITY - A COMPARATIVE-STUDY OF THE BIOLOGICAL EFFECTS OF POLY(ADP-RIBOSE) POLYMERASE INHIBITORS [J].

BOULTON, S ;

PEMBERTON, LC ;

PORTEOUS, JK ;

CURTIN, NJ ;

GRIFFIN, RJ ;

GOLDING, BT ;

DURKACZ, BW .

BRITISH JOURNAL OF CANCER, 1995, 72 (04) :849-856

[7] Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma [J].

Bower, M ;

Newlands, ES ;

Bleehen, NM ;

Brada, M ;

Begent, RJH ;

Calvert, H ;

Colquhoun, I ;

Lewis, P ;

Brampton, MH .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1997, 40 (06) :484-488

[8]

BRADA M, 1995, P AN M AM SOC CLIN, V14, P470

[9]

BRANDES A, 1991, ANTICANCER RES, V11, P719

[10] The role of chemotherapy in recurrent malignant gliomas: An overview [J].

Brandes, AA ;

Fiorentino, MV .

CANCER INVESTIGATION, 1996, 14 (06) :551-558

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