FcγR polymorphisms:: Implications for function, disease susceptibility and immunotherapy

被引：230

作者：

van Sorge, NM ^{[1
]}

van der Pol, WL ^{[1
]}

van de Winkel, JGJ ^{[1
]}

机构：

[1] UMC, Immunol Neurol, Utrecht, Netherlands

来源：

TISSUE ANTIGENS | 2003年 / 61卷 / 03期

关键词：

D O I：

10.1034/j.1399-0039.2003.00037.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Leukocyte Fcgamma receptors (FcgammaR) confer potent cellular effector functions to the specificity of IgG. FcgammaR-induced leukocyte functions, including antibody-dependent cellular cytotoxicity, phagocytosis, superoxide generation, degranulation, cytokine production and regulation of antibody production, are essential for host defense and immune regulation. The efficacy of IgG-induced FcgammaR function displays inter-individual heterogeneity due to genetic polymorphisms of three FcgammaR subclasses, FcgammaRIIa (CD32a), FcgammaRIIIa (CD16a), and FcgammaRIIIb (CD16b). FcgammaR polymorphisms have been associated with infectious and autoimmune disease, or with disease severity. FcgammaR polymorphisms may furthermore serve as markers for therapeutic efficacy and side-effects of treatment with monoclonal antibodies. In this review, FcgammaR function and the relevance of FcgammaR polymorphisms as prognostic markers for inflammatory disease and antibody-based immunotherapy are discussed.

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页码：189 / 202

页数：14

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