Atomic force microscopy with time resolution of microseconds

被引：10

作者：

Anwar, M

Rousso, I ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, BioImaging Ctr, Cambridge, MA 02142 USA

[2] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[4] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA

来源：

APPLIED PHYSICS LETTERS | 2005年 / 86卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.1843277

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The atomic force microscope (AFM) can acquire high-resolution images under nondestructive conditions albeit at a very poor temporal resolution. This work presents two AFM mapping techniques, stroboscopic, and continuous, for imaging rapid periodical processes with nanometer spatial resolution and microsecond time resolution. Application of these methods is demonstrated for imaging very rapid cyclic changes in the position of a microfabricated grid. Motion was resolved with 10 nm spatial resolution, and 5 and 25 mus temporal resolution using the stroboscopic and continuous mode, respectively. The proposed methods have the potential to image wide variety of rapid processes with unparalleled combination of lateral and temporal resolutions. (C) 2005 American Institute of Physics.

引用

页码：014101 / 1

页数：3

共 7 条

[1] A high-speed atomic force microscope for studying biological macromolecules in action [J].