Inhibition of Salmonella Host Cell Invasion by Dimethyl Sulfide

被引：23

作者：

Antunes, L. Caetano M. ^{[1
]}

Buckner, Michelle M. C. ^{[1
,2
]}

Auweter, Sigrid D. ^{[1
]}

Ferreira, Rosana B. R. ^{[1
]}

Lolic, Petra ^{[1
,2
]}

Finlay, B. Brett ^{[1
,2
]}

机构：

[1] Univ British Columbia, Michael Smith Lab, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2010年 / 76卷 / 15期

基金：

瑞士国家科学基金会; 加拿大健康研究院;

关键词：

III SECRETION SYSTEM; ESCHERICHIA-COLI; SULFOXIDE REDUCTASE; TYPHIMURIUM; VIRULENCE; GENES; MUTANTS; SULFUR; IDENTIFICATION; DEGRADATION;

D O I：

10.1128/AEM.00851-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We show that dimethyl sulfoxide (DMSO) inhibits Salmonella hilA expression and that this inhibition is stronger under anaerobiosis. Because DMSO can be reduced to dimethyl sulfide (DMS) during anaerobic growth, we hypothesized that DMS was responsible for hilA inhibition. Indeed, DMS strongly inhibited the expression of hilA and multiple Salmonella pathogenicity island 1 (SPI-1)-associated genes as well as the invasion of cultured epithelial cells. Because DMSO and DMS are widespread in nature, we hypothesize that this phenomenon may contribute to environmental sensing by Salmonella.

引用

页码：5300 / 5304

页数：5

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