Targeting death and decoy receptors of the tumour-necrosis factor superfamily

被引：1071

作者：

Ashkenazi, A ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期

关键词：

D O I：

10.1038/nrc821

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cells often develop resistance to chemotherapy or irradiation through mutations in the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular damage. Death receptors - members of the tumour-necrosis factor receptor (TNFR) superfamily - signal apoptosis independently of p53. Decoy receptors, by contrast, are a non-signalling subset of the TNFR superfamily that attenuate death-receptor function. Agents that are designed to activate death receptors (or block decoy receptors) might therefore be used to kill tumour cells that are resistant to conventional cancer therapies.

引用

页码：420 / 430

页数：11

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