Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease

被引：113

作者：

Chen, Chiung Chu ^{[1
,2
]}

Hsu, Yi Ting ^{[3
]}

Chan, Hsiao Lung ^{[4
]}

Chiou, Shang Ming ^{[5
]}

Tu, Po Hsun ^{[6
]}

Lee, Shih Tseng ^{[6
]}

Tsai, Chon Haw ^{[3
,7
]}

Lu, Chin Song ^{[1
,2
]}

Brown, Peter ^{[8
]}

机构：

[1] Chang Gung Mem Hosp & Univ, Dept Neurol, Taipei, Taiwan

[2] Chang Gung Mem Hosp, Neurosci Res Ctr, Taipei 10591, Taiwan

[3] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[4] Chang Gung Univ, Dept Elect Engn, Taipei, Taiwan

[5] China Med Univ Hosp, Dept Neurosurg, Taichung, Taiwan

[6] Chang Gung Mem Hosp & Univ, Dept Neurosurg, Taipei, Taiwan

[7] China Med Univ, Grad Inst Neural & Cognit Sci, Taichung, Taiwan

[8] UCL, Inst Neurol, London, England

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 224卷 / 01期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease synchronisation; Lempel-Ziv complexity; Subthalamic nucleus; Deep brain stimulation; LEMPEL-ZIV COMPLEXITY; BASAL GANGLIA; PATHOLOGICAL SYNCHRONIZATION; NUCLEUS STIMULATION; ALZHEIMERS-DISEASE; MOTOR-PERFORMANCE; NEURONAL-ACTIVITY; BETA-ACTIVITY; DOPAMINE; TREMOR;

D O I：

10.1016/j.expneurol.2010.03.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Excessive synchronization of the basal ganglia neuronal activity in the 13- to 35-Hz frequency band, so-called beta activity, has been associated with the motor deficits of Parkinson's disease (PD). Studies have demonstrated that beta activity may be suppressed by treatment with dopaminergic medication and high-frequency stimulation of the subthalamic nucleus (STN), with the degree of suppression correlating with clinical improvement. However, these studies failed to demonstrate any correlation between beta activity of parkinsonism in the resting, untreated state. This argues against a significant relationship between beta activity and motor impairment. Here we use an advanced nonlinear dynamical analysis method based on the Lempel-Ziv estimator to show frequency band and symptom-subset specific correlations between STN local field potential (LFP) complexity and motor impairment in PD patients. Oscillatory activity has a reduced complexity, and we found a strong negative correlation between the complexity of the STN LFP over the 13- to 35-Hz frequency range and akinesia-rigidity. There was no such correlation with tremor. Furthermore, there was no correlation between LFP Lempel-Ziv complexity (LZC) over the 0- to 12-Hz frequency band and any parkinsonian motor impairment. The results strengthen the association between the dynamic structure of synchonised (LFP) activity in the beta frequency band in the STN and akinesia-rigidity. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：234 / 240

页数：7

共 44 条

[1]

.Interpretation of the Lempel-Ziv complexity measure in the context of biomedical signal analysis [J].

Aboy, Mateo ;

Hornero, Roberto ;

Abasolo, Daniel ;

Alvarez, Daniel .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2006, 53 (11) :2282-2288

[2]

Hippocampal Gamma Oscillations in Rats Estimation of Complexity Levels Using Brain-Slice Recordings and Lempel-Ziv Estimator [J].

Akay, Yasemin M. ;

Dragomir, Andrei ;

Song, Chuanze ;

Wu, Jie ;

Akay, Metin .

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2009, 28 (06) :92-95

[3]

Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients [J].

Amirnovin, R ;

Williams, ZM ;

Cosgrove, GR ;

Eskandar, EN .

JOURNAL OF NEUROSCIENCE, 2004, 24 (50) :11302-11306

[4]

Amplitude modulation of oscillatory activity in the subthalamic nucleus during movement [J].

Androulidakis, Alexandros G. ;

Bruecke, Christof ;

Kempf, Florian ;

Kupsch, Andreas ;

Aziz, Tipu ;

Ashkan, Keyoumars ;

Kuehn, Andrea A. ;

Brown, Peter .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (05) :1277-1284

[5]

EVALUATION OF THE DISPERSIONAL ANALYSIS METHOD FOR FRACTAL TIME-SERIES [J].

BASSINGTHWAIGHTE, JB ;

RAYMOND, GM .

ANNALS OF BIOMEDICAL ENGINEERING, 1995, 23 (04) :491-505

[6]

THE PRIMATE SUBTHALAMIC NUCLEUS .2. NEURONAL-ACTIVITY IN THE MPTP MODEL OF PARKINSONISM [J].

BERGMAN, H ;

WICHMANN, T ;

KARMON, B ;

DELONG, MR .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :507-520

[7]

Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates [J].

Bergman, H ;

Feingold, A ;

Nini, A ;

Raz, A ;

Slovin, H ;

Abeles, M ;

Vaadia, E .

TRENDS IN NEUROSCIENCES, 1998, 21 (01) :32-38

[8]

Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network [J].

Bevan, MD ;

Magill, PJ ;

Terman, D ;

Bolam, JP ;

Wilson, CJ .

TRENDS IN NEUROSCIENCES, 2002, 25 (10) :525-531

[9]

Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [J].

Brown, P ;

Oliviero, A ;

Mazzone, P ;

Insola, A ;

Tonali, P ;

Di Lazzaro, V .

JOURNAL OF NEUROSCIENCE, 2001, 21 (03) :1033-1038

[10]

Basal ganglia local field potential activity: Character and functional significance in the human [J].

Brown, P ;

Williams, D .

CLINICAL NEUROPHYSIOLOGY, 2005, 116 (11) :2510-2519

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