Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine

被引：32

作者：

Billaut-Mulot, O

Idziorek, T

Ban, E

Kremer, L

Dupré, L

Loyens, M

Riveau, G

Locht, C

Capron, A

Bahr, GM

机构：

[1] Inst Pasteur Lille, Unite Inserm 167, F-59019 Lille, France

[2] Inst Pasteur Lille, Unite Inserm 447, F-59019 Lille, France

来源：

VACCINE | 2000年 / 19卷 / 01期

关键词：

DNA vaccination; IL-18; HIV;

D O I：

10.1016/S0264-410X(00)00157-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many different HIV-1 vaccine strategics have been developed, but as yet none has been completely successful. Promising results from combined DNA prime/protein boost vaccines have been reported. Specific immune responses generated by DNA vaccines carl be modulated by the co-delivery of genes coding for cytokines, In this study, we have used the intradermal route by needle injection of a plasmid coding for the HIV-1 Nef accessory protein. We show that DNA prime/protein boost vaccine combinations increase the humoral and cellular immune responses against HIV-1 Nef and that the co-injection of DNA encoding Interleukin-18 (IL-18) modulates the specific immune response towards a Th1 type, (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：95 / 102

页数：8

共 32 条

[1] An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV [J].