Present difficulties and future promise of MHC multimers in autoimmune exploration

被引：20

作者：

Ferlin, W ^{[1
]}

Glaichenhaus, N ^{[1
]}

Mougneau, E ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Valbonne, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(00)00161-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Class I tetramers have been used to track cytotoxic T cells during bacterial and viral infections. During the past year, the use of such molecules has revealed important information about the role of CD8(+) T cells in autoimmune diabetes. Furthermore, class II multimers have been produced and successfully used to stain autoreactive CD4(+) T cells from patients with rheumatoid arthritis or Borrelia-borgdorferi-induced Lyme arthritis.

引用

页码：670 / 675

页数：6

共 49 条

[1] Phenotypic analysis of antigen-specific T lymphocytes
Altman, JD
Moss, PAH
Goulder, PJR
Barouch, DH
McHeyzerWilliams, MG
Bell, JI
McMichael, AJ
Davis, MM
[J]. SCIENCE, 1996, 274 (5284) : 94 - 96
[2] Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
Amrani, A
Verdaguer, J
Serra, P
Tafuro, S
Tan, RS
Santamaria, P
[J]. NATURE, 2000, 406 (6797) : 739 - 742
[3] Kinetics of T-cell receptor binding by bivalent HLA-DR•peptide complexes that activate antigen-specific human T-cells
Appel, H
Gauthier, L
Pyrdol, J
Wucherpfennig, KW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) : 312 - 321
[4] Baldwin KK, 1999, J IMMUNOL, V163, P689
[5] In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers
Benlagha, K
Weiss, A
Beavis, A
Teyton, L
Bendelac, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (11) : 1895 - 1903
[6] Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding
Bodinier, M
Peyrat, MA
Tournay, C
Davodeau, F
Romagne, F
Bonneville, M
Lang, F
[J]. NATURE MEDICINE, 2000, 6 (06) : 707 - 710
[7] BURMESTER GR, 1995, ANNU REV IMMUNOL, V13, P229, DOI 10.1146/annurev.iy.13.040195.001305
[8] Regulation of encephalitogenic T cells with recombinant TCR ligands
Burrows, GG
Adlard, KL
Bebo, BF
Chang, JW
Tenditnyy, K
Vandenbark, AA
Offner, H
[J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (12) : 6366 - 6371
[9] Engineering and characterization of a murine MHC class II-immunoglobulin chimera expressing an immunodominant CD4 T viral epitope
Casares, S
Bona, CA
Brumeanu, TD
[J]. PROTEIN ENGINEERING, 1997, 10 (11): : 1295 - 1301
[10] The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
Cochran, JR
Cameron, TO
Stern, LJ
[J]. IMMUNITY, 2000, 12 (03) : 241 - 250

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