The first cell membranes

被引:183
作者
Deamer, D [1 ]
Dworkin, JP
Sandford, SA
Bernstein, MP
Allamandola, LJ
机构
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA
[3] Ctr Study Life Universe, SETI Inst, Mountain View, CA USA
关键词
membranes; amphiphiles; self-assembly; prebiotic;
D O I
10.1089/153110702762470482
中图分类号
P1 [天文学];
学科分类号
0704 ;
摘要
Organic compounds are synthesized in the interstellar medium and can be delivered to planetary surface's such as the early Earth, where they mix with endogenous species. Some of these compounds are. amphiphilic, having polar and nonpolar groups on the same molecule. Amphiphilic compounds spontaneously self-assemble into more complex structures such as bimolecular layers, which in turn form closed membranous vesicles. The first forms of cellular life required self-assembled membranes that were likely to have been produced from amphiphilic compounds on the prebiotic Earth. Laboratory simulations show that such vesicles readily encapsulate functional macromolecules, including nucleic acids and polymerases. The goal of future investigations will be to fabricate artificial cells as models of the origin of life.
引用
收藏
页码:371 / 381
页数:11
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