Protective effect of passive immunization against TNF-α in mice infected with Sendai virus

被引：2

作者：

Iwai, H

Morioka, A

Shoya, Y

Obata, Y

Goto, M

Kirisawa, R

Okada, H

Yoshino, T

机构：

[1] Rakuno Gakuen Univ, Dept Vet Microbiol, Fac Vet Med, Ebetsu, Hokkaido 069, Japan

[2] Rakuno Gakuen Univ, Dept Vet Pathol, Fac Vet Med, Ebetsu, Hokkaido 069, Japan

来源：

EXPERIMENTAL ANIMALS | 1998年 / 47卷 / 01期

关键词：

mouse; Sendai virus; TNF-alpha;

D O I：

10.1538/expanim.47.49

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

TNF-alpha has been reported to be induced in mice infected with Sendai virus. We evaluated the role of TNF-alpha in the virus infection. TNF-alpha was induced locally in proportion to virus titers in the lung. The activity was correlated with suppression of body weight gain. Passive immunization against TNF-alpha improved body weight gain and ameliorated pneumonic lesions in infected mice, and prevented them from lethal infection, but lung virus titers were not affected by passive immunization. These results indicate that Sendai virus-induced emaciation, pneumonic lesions and death were mediated by TNF-alpha.

引用

页码：49 / 54

页数：6

共 27 条

[1]

ADERKA D, 1986, J IMMUNOL, V136, P2938

[2]

APPELL LH, 1971, AM J VET RES, V32, P1835

[3]

ARNOLD R, 1995, IMMUNOLOGY, V85, P364

[4] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN [J].