Blood manganese content at birth and cord serum prolactin levels

被引：32

作者：

Takser, L

Mergler, D

de Grosbois, S

Smargiassi, A

Lafond, J

机构：

[1] Univ Quebec, CINBIOSE, Montreal, PQ H3C 3P8, Canada

[2] Univ Quebec, Dept Biol Sci, Lab Physiol Materno Foetale, Montreal, PQ H3C 3P8, Canada

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 2004年 / 26卷 / 06期

关键词：

manganese; prolactin; cord blood;

D O I：

10.1016/j.ntt.2004.07.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Manganese (Mn) is both an essential element and, at a high dose, a potent neurotoxin that can interact with dopaminergic neurotransmission. Plasma prolactin (PRL), an indirect indicator of dopaminergic functioning, has been shown to vary with Mn exposure in adults, but little is known about this relation in the developing brain. The objective of this study was to examine the relations between maternal and cord Mn blood concentrations at birth and PRL cord blood levels. Blood Mn levels were determined in 87 pregnant women at delivery, and PRL was measured in the cord blood plasma. Mn cord blood concentration (mean 34.4 mug/l, range 16.7-89.4) was significantly and positively related to cord PRL levels. These findings suggest that Mn accumulation in utero could contribute to PRL level variation in neonates, which, in turn, may influence important developmental parameters. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：811 / 815

页数：5

共 39 条

[1] INTERFERENCE OF MANGANESE ON NEUROENDOCRINAL SYSTEM IN EXPOSED WORKERS - PRELIMINARY-REPORT [J].