Interferon beta normalizes suppressor cell function in dysimmune neuropathies

被引：21

作者：

De Luca, G ^{[1
]}

Lugaresi, A ^{[1
]}

Iarlori, C ^{[1
]}

Marzoli, F ^{[1
]}

Uncini, A ^{[1
]}

Gambi, D ^{[1
]}

机构：

[1] Univ Chieti, Dept Oncol & Neurosci, Ctr Neuromuscular Dis, Policlin Clin Colle Ara, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 82卷 / 01期

关键词：

chronic inflammatory demyelinating polyneuropathy; myelin associated glycoprotein; sulfated glucuronyl paragloboside; suppressor cell function; recombinant human IFN beta 1a;

D O I：

10.1016/S0165-5728(97)00170-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon beta, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon beta might represent an adjunctive therapy in CIDP both acting on a defective blood-nerve barrier and normalizing an otherwise defective suppressor cell function. (C) 1998 Elsevier Science B.V.

引用

页码：1 / 4

页数：4

共 19 条

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