Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders

被引：24

作者：

Chen, Huazhong ^{[1
]}

Liu, Shelan ^{[2
]}

Liu, Jun ^{[3
]}

Chai, Chengliang ^{[2
]}

Mao, Haiyan ^{[2
]}

Yu, Zhao ^{[2
]}

Tang, Yuming ^{[4
]}

Zhu, Geqin ^{[5
]}

Chen, Haixiao X. ^{[1
]}

Zhu, Chengchu ^{[1
]}

Shao, Hui ^{[1
]}

Tan, Shuguang ^{[6
]}

Wang, Qianli ^{[6
]}

Bi, Yuhai ^{[6
]}

Zou, Zhen ^{[7
]}

Liu, Guang ^{[8
,9
]}

Jin, Tao ^{[9
]}

Jiang, Chengyu ^{[7
]}

Gao, George F. ^{[3
,6
]}

Peiris, Malik ^{[10
]}

Yu, Hongjie ^{[11
]}

Chen, Enfu ^{[2
]}

机构：

[1] Taizhou Hosp, Wenzhou Med Coll, Taizhou, Peoples R China

[2] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

[4] Linhai Dist Ctr Dis Control & Prevent, Taizhou, Peoples R China

[5] Jiaojiang Dist Ctr Dis Control & Prevent, Taizhou, Peoples R China

[6] Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China

[7] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[8] Univ Chinese Acad Sci, Beijing, Peoples R China

[9] BGI Shenzhen, Shenzhen, Peoples R China

[10] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[11] Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, 155 Changbai Rd, Beijing 102206, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 04期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; A H7N9 VIRUS; TO-PERSON TRANSMISSION; HUMAN INFECTIONS; CHINA; RISK; HYPERCYTOKINEMIA; SPECTRUM; VACCINE;

D O I：

10.3201/eid2204.151561

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man with chronic lymphocytic leukemia who had been occupationally exposed to poultry. He had co-infection with H7N9 and pH1N1 viruses. A 71-year-old man with polycythemia vera who was in the same ward as the index case-patient for 6 days acquired infection with H7N9 and pH1N1 viruses. The incubation period for the second case-patient was estimated to be <= 4 days. Both case-patients died of multiple organ failure. Virus genetic sequences from the 2 case-patients were identical. Of 103 close contacts, none had acute respiratory symptoms; all were negative for H7N9 virus. Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. These findings strongly suggest limited nosocomial co-transmission of H7N9 and pH1N1 viruses from 1 immunocompromised patient to another.

引用

页码：598 / 607

页数：10

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