Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin

被引:30
作者
Cha, JH [1 ]
Chang, MY
Richardson, JA
Eidels, L
机构
[1] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA
[3] Yonsei Univ, Coll Dent, Dept Oral Biol, Oral Sci Res Ctr, Seoul 120749, South Korea
关键词
D O I
10.1046/j.1365-2958.2003.03550.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until recently. The receptor was identified by its ability to confer toxin-sensitivity to mouse cells, which are normally toxin-resistant. Although mice are also naturally resistant, we now demonstrate that transgenic mice expressing the diphtheria toxin receptor are as sensitive to the toxin as are humans and other toxin-sensitive animals. These transgenic mice provide a suitable model for studying modern antidotes for diphtheria.
引用
收藏
页码:235 / 240
页数:6
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