Adoption study of environmental modifications of the genetic influences on obesity

被引:36
作者
Sorensen, TIA
Holst, C
Stunkard, AJ
机构
[1] Copenhagen Univ Hosp, Inst Prevent Med, Danish Epidemiol Sci Ctr, Copenhagen, Denmark
[2] Univ Copenhagen, Dept Biostat, Copenhagen, Denmark
[3] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
关键词
adoption study; body mass index; environmental indicators; familial occurrence; genetics; obesity; smoking; social class;
D O I
10.1038/sj.ijo.0800548
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: Adult body mass index (BMI weight (kg)/height(2) (m(2))) usually shows familial correlations below 0.3, which are almost entirely due to genetic influences. The considerable remaining non-familial individual variation may be due to non-shared environmental influences which, however, may interact with or modify the genetic influence. OBJECTIVE: To investigate whether the genetic influence on adult BMI is modified by various obesity-related environmental conditions during childhood and adulthood. DESIGN: Adoption study, in which the genetic influence is assessed by the correlations in adult BMI between adoptees and their biological fathers, mothers and full siblings. These correlations were compared between groups of families characterized by differences in rearing or adult environment of the adoptees and/or their biological relatives. SUBJECTS: Height, current weight and greatest weight ever, were obtained in 3651 subjects, who were adopted by non-related families in Copenhagen between 1924 and 1947. Groups representing thin, medium weight, overweight and obese proband adoptees were selected by current BMI (n = 540) and by maximum BMI (n = 524). The members of the biological and adoptive families of the proband adoptees were identified and their BMI was computed from height and weight obtained by mailed questionnaires. MAIN VARIABLES: Indicators related to the rearing environment of the adoptees were age of the adoptee at transfer to the adoptive family, region of residence, presence of adoptive siblings and, for the adoptive parents, year of birth, age at time of adoption, occupational rating, smoking habits and BMI. Indicators of the environment of both the adoptee and the biological relatives were: year of birth; occupational rating and smoking habits, and, of the environment of the biological parents, age and parity at birth of the adoptee. RESULTS: The correlations in BMI between adoptees and the biological fathers, mothers and siblings were 0.11, 0.15 and 0.26 for adoptees selected by current BMI, and 0.13, 0.16, and 0.27 for adoptees selected by maximum BMI, respectively (all P < 0.001), demonstrating the previously reported genetic influence, None of the environmental indicators showed consistent and significant effects on these six correlations. The same negative results were obtained in analysis of environmental indicators applied to the two adoptive parents together or to the adoptee and the biological relatives together. CONCLUSION: The genetic influence on BMI was unaffected by several different environmental conditions otherwise associated with obesity.
引用
收藏
页码:73 / 81
页数:9
相关论文
共 34 条
[1]  
ALLISON DB, 1995, INT J OBESITY, V19, P397
[2]   THE ANALYSIS AND IDENTIFICATION OF HOMOLOGIZER MODERATOR VARIABLES WHEN THE MODERATOR IS CONTINUOUS - AN ILLUSTRATION WITH ANTHROPOMETRIC DATA [J].
ALLISON, DB ;
HESHKA, S ;
PIERSON, RN ;
WANG, J ;
HEYMSFIELD, SB .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 1992, 4 (06) :775-782
[3]  
[Anonymous], GENETICS OBESITY
[4]  
[Anonymous], 1994, GENETICS OBESITY
[5]   THE RESPONSE TO LONG-TERM OVERFEEDING IN IDENTICAL-TWINS [J].
BOUCHARD, C ;
TREMBLAY, A ;
DESPRES, JP ;
NADEAU, A ;
LUPIEN, PJ ;
THERIAULT, G ;
DUSSAULT, J ;
MOORJANI, S ;
PINAULT, S ;
FOURNIER, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (21) :1477-1482
[6]  
Bouchard C, 1994, Obes Res, V2, P400
[7]   NONRANDOM SAMPLING IN HUMAN-GENETICS - ESTIMATION OF FAMILIAL CORRELATIONS, MODEL TESTING, AND INTERPRETATION [J].
CHAKRABORTY, R ;
HANIS, CL .
STATISTICS IN MEDICINE, 1987, 6 (05) :629-646
[8]   CHILDHOOD ANTECEDENTS OF ADULT OBESITY - DO CHUBBY INFANTS BECOME OBESE ADULTS [J].
CHARNEY, E ;
GOODMAN, HC ;
MCBRIDE, M ;
LYON, B ;
PRATT, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (01) :6-9
[9]   ESTIMATION OF A SIMPLE REGRESSION COEFFICIENT IN SAMPLES ARISING FROM A SUB-SAMPLING PROCEDURE [J].
DEMETS, D ;
HALPERIN, M .
BIOMETRICS, 1977, 33 (01) :47-56
[10]   Identification of two novel missense mutations in the human OB gene [J].
Echwald, SM ;
Rasmussen, SB ;
Sorensen, TIA ;
Andersen, T ;
TybjaergHansen, A ;
Clausen, JO ;
Hansen, L ;
Hansen, T ;
Pedersen, O .
INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (04) :321-326