Serum α-fetoprotein levels in Beckwith-Wiedemann syndrome

被引：52

作者：

Everman, DB

Shuman, C

Dzolganovski, B

O'Riordan, MA

Weksberg, R

Robin, NH

机构：

[1] Univ Hosp Cleveland, Ctr Human Genet, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Ctr Human Genet, Cleveland, OH USA

[3] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH USA

[4] Case Western Reserve Univ, Sch Med, Dept Pediat, Cleveland, OH USA

[5] Case Western Reserve Univ, Sch Med, Div Clin Epidemiol, Cleveland, OH USA

[6] Hosp Sick Children, Div Clin & Metab Genet, Toronto, ON M5G 1X8, Canada

[7] Univ Toronto, Toronto, ON, Canada

来源：

JOURNAL OF PEDIATRICS | 2000年 / 137卷 / 01期

关键词：

D O I：

10.1067/mpd.2000.106217

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwitth-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal per;od at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.

引用

页码：123 / 127

页数：5

共 15 条

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