IPy2BF4-promoted intramolecular addition of masked and unmasked anilines to alkynes:: Direct assembly of 3-iodoindole cores

被引：295

作者：

Barluenga, J ^{[1
]}

Trincado, M ^{[1
]}

Rubio, E ^{[1
]}

González, JM ^{[1
]}

机构：

[1] Univ Oviedo, CSIC, Unidad Asociada, Inst Quim Organomet Enrique Moles, E-33071 Oviedo, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 21期

关键词：

alkynes; cyclization; electrophilic addition; halogenation; nitrogen heterocycles;

D O I：

10.1002/anie.200351303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All at once! Indoles can be assembled and iodinated in a one-pot process (see scheme) from anilines and their derivatives. This metal-free addition of nitrogen compounds to alkynes is a clean reaction that is promoted by iodonium cations. Such a process provides a general pathway towards utilization of the biologically relevant indole core.

引用

页码：2406 / 2409

页数：4

共 72 条

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