Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain

被引:10
作者
McGrath, KE [1 ]
Seidler, FJ [1 ]
Slotkin, TA [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA
来源
DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 104卷 / 1-2期
关键词
brain development; cocaine; dexamethasone; glucocorticoid; paroxetine; serotonin; transporter;
D O I
10.1016/S0165-3806(97)00144-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Serotonin plays a trophic role in brain cell differentiation. In this study, expression of the serotonin presynaptic transporter protein, which regulates the extracellular serotonin concentration, was measured with [H-3]paroxetine in rats exposed to dexamethasone or cocaine prenatally. Within 24 h of a single dose of dexamethasone, significant increases were seen in fetal brain, and the effect persisted into the postnatal period. Chronic prenatal cocaine exposure elicited similar changes. These data indicate that exposures to apparently disparate drugs can elicit similar endpoints that may lead to behavioral teratogenesis. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:209 / 213
页数:5
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