The thyroid hormone down-regulates the mouse α-foetoprotein promoter

被引：7

作者：

Caturla, M ^{[1
]}

Van Reeth, T ^{[1
]}

Drèze, P ^{[1
]}

Szpirer, J ^{[1
]}

Szpirer, C ^{[1
]}

机构：

[1] Free Univ Brussels, Dept Biol Mol, B-1640 Rhode St Genese, Belgium

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1997年 / 135卷 / 02期

关键词：

alpha-foetoprotein; thyroid hormone; nTRE; hepatoma cells;

D O I：

10.1016/S0303-7207(97)00196-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The thyroid hormone (T3) was shown to down regulate the level of alpha-foetoprotein (AFP) mRNA in hepatoma cells HepG2. Recombinant plasmids containing segments from the mouse AFP gene promoter were transfected in HepG2 cells and transient expression assays showed that the T3 inhibitory effect depends on the sequence limited by positions -80 and -38, upstream from the TATA box. This sequence is able to confer T3 sensitivity to a heterologous promoter and contains a putative T3-responsive element, as well as likely CEBP- and HNF1-responsive elements. These observations suggest that T3 is a good candidate for hormonal control of the AFP gene expression and especially for the neonatal shut off of the gene. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：139 / 145

页数：7

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