BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration

被引：162

作者：

Barrientos, RM

Sprunger, DB

Campeau, S

Watkins, LR

Rudy, JW

Maier, SF

机构：

[1] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 155卷 / 1-2期

关键词：

memory consolidation; time course; proinflammatory cytokines; BDNF; intrahippocampal; in situ hybridization;

D O I：

10.1016/j.jneuroim.2004.06.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA 1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：119 / 126

页数：8

共 58 条

[1] BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation [J].