New developments in FcεRI regulation, function and inhibition

被引：445

作者：

Kraft, Stefan ^{[1
]}

Kinet, Jean-Pierre ^{[1
]}

机构：

[1] Harvard Inst Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Lab Allergy & Immunol, Boston, MA 02215 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 05期

关键词：

D O I：

10.1038/nri2072

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The high-affinity Fc receptor for IgE (Fc epsilon RI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of Fc epsilon RI. The first area relates to Fc epsilon RI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by Fc epsilon RI; and the third area relates to the accumulated evidence for the tight control of Fc epsilon RI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.

引用

收藏

页码：365 / 378

页数：14

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