The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors

被引：60

作者：

Hamza, Taye H. ^{[1
]}

Payami, Haydeh ^{[1
]}

机构：

[1] Wadsworth Ctr, New York State Dept Hlth, Div Genet, Albany, NY 12201 USA

来源：

JOURNAL OF HUMAN GENETICS | 2010年 / 55卷 / 04期

基金：

美国国家卫生研究院;

关键词：

age at onset; environment; gene; heritability; PD; risk; COMPLEX SEGREGATION ANALYSIS; FAMILIAL AGGREGATION; ALPHA-SYNUCLEIN; ASSOCIATION;

D O I：

10.1038/jhg.2010.13

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

We questioned whether the evidence for the genetic component in Parkinson's disease (PD) in Caucasians could be explained by the causative and susceptibility genes that have already been identified. We estimated heritability of risk and age at onset of PD in a well-characterized sample of 504 nuclear families (2828 individuals). After excluding families with known pathogenic mutations and accounting for the major susceptibility genes, the heritability of risk of developing PD was 0.41 (P=0.01). These data suggest that similar to 40% of the variation in susceptibility to PD is due to as-yet unidentified genes, the remainder is likely environmental. Journal of Human Genetics ( 2010) 55, 241-243; doi:10.1038/jhg.2010.13; published online 5 March 2010

引用

页码：241 / 243

页数：3

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