Carnitine acts as a compatible solute in Brevibacterium linens

被引：15

作者：

Jebbar, M ^{[1
]}

Champion, C ^{[1
]}

Blanco, C ^{[1
]}

Bonnassie, S ^{[1
]}

机构：

[1] Univ Rennes 1, Dept Membranes & Osmoregulat, Lab Genet & Physiol Microbiennes, CNRS UPRES A 6026, F-35042 Rennes, France

来源：

RESEARCH IN MICROBIOLOGY | 1998年 / 149卷 / 03期

关键词：

carnitine; Brevibacterium linens; glycine betaine; ectoine; osmotic stress; osmoprotection;

D O I：

10.1016/S0923-2508(98)80081-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Carnitine is a trimethyl amino acid found at relatively high concentrations in materials of animal origin. Exogenously provided L-carnitine was found to stimulate growth of Brevibacterium linens ATCC 19391 in media with inhibitory osmotic strength. Its osmoprotective ability was as potent as that of glycine betaine. Electrophoretic and spectroscopic (NMR) analysis showed that this compound is only transiently accumulated, but in significant amounts, by B. linens under hyperosmotic stress and is converted into glycine betaine. The L-carnitine/glycine betaine pathway is inducible by L-carnitine in B. linens. The D-enantiomer did not improve growth of B. linens, even though this solute is accumulated by B. linens at the same level as glycine betaine. The two isomeric forms of carnitine repress the build-up of ectoine, the main endogenous osmolyte in B. linens.

引用

页码：211 / 219

页数：9

共 36 条

[1] QUATERNARY AMMONIUM-COMPOUNDS IN THE BIOSPHERE - AN EXAMPLE OF A VERSATILE ADAPTIVE STRATEGY [J].