共 15 条
Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
被引:163
作者:

Chun, Tae-Wook
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Justement, J. Shawn
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Moir, Susan
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Hallahan, Claire W.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Maenza, Janine
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Mullins, James I.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Collier, Ann C.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Corey, Lawrence
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

Fauci, Anthony S.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
机构:
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
[2] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA
[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[4] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA
关键词:
D O I:
10.1086/518250
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The persistence of latently infected resting CD4(+) T cells has been clearly demonstrated in human immunodeficiency virus (HIV)-infected individuals receiving effective antiviral therapy. However, estimates of the half-life of this viral reservoir have been quite divergent. We demonstrate clear evidence for decay of this HIV reservoir in patients who initiated antiviral therapy early in infection. The half-life of this latent viral reservoir was estimated to be 4.6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4(+) T cells in infected individuals who initiate antiviral therapy early in HIV infection.
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页码:1762 / 1764
页数:3
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