Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus

被引:163
作者
Chun, Tae-Wook
Justement, J. Shawn
Moir, Susan
Hallahan, Claire W.
Maenza, Janine
Mullins, James I.
Collier, Ann C.
Corey, Lawrence
Fauci, Anthony S.
机构
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
[2] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA
[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[4] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA
关键词
D O I
10.1086/518250
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The persistence of latently infected resting CD4(+) T cells has been clearly demonstrated in human immunodeficiency virus (HIV)-infected individuals receiving effective antiviral therapy. However, estimates of the half-life of this viral reservoir have been quite divergent. We demonstrate clear evidence for decay of this HIV reservoir in patients who initiated antiviral therapy early in infection. The half-life of this latent viral reservoir was estimated to be 4.6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4(+) T cells in infected individuals who initiate antiviral therapy early in HIV infection.
引用
收藏
页码:1762 / 1764
页数:3
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