The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating

被引：154

作者：

Fischer, M

Schnell, N

Chattaway, J

Davies, P

Dixon, G

Sanders, D

机构：

[1] Univ York, Dept Biol, York YO1 5YW, N Yorkshire, England

[2] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

FEBS LETTERS | 1997年 / 419卷 / 2-3期

基金：

英国生物技术与生命科学研究理事会;

关键词：

calcium channel; CCH1; mating; Saccharomyces cerevisiae;

D O I：

10.1016/S0014-5793(97)01466-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel alpha 1-subunit genes. Knock-out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca2+ influx in response to the alpha-mating pheromone. Cch1 is involved in calcium influx and the late stage of the mating process. The cch1 mutant sensitivity against the alpha-mating pheromone can be reduced by the addition of extra calcium. The product of this gene is likely to interact with the MID1 gene product in Ca influx or its control. (C) 1997 Federation of European Biochemical Societies.

引用

页码：259 / 262

页数：4

共 16 条

[1] CELL-CYCLE CONTROL BY CALCIUM AND CALMODULIN IN SACCHAROMYCES-CEREVISIAE [J].