KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

被引：122

作者：

Tsukada, Yu-ichi ^{[1
,2
,3
]}

Ishitani, Tohru ^{[4
]}

Nakayama, Keiichi I. ^{[1
,2
]}

机构：

[1] Kyushu Univ, Div Cell Biol, Med Inst Bioregulat, Higashi Ku, Fukuoka 8128582, Japan

[2] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[4] Kyushu Univ, Div Cell Regulat Syst, Med Inst Bioregulat, Higashi Ku, Fukuoka 8128582, Japan

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 05期

关键词：

Demethylase; JmjC; methylation; histone; chromatin; epigenetics; CLEFT LIP/CLEFT PALATE; DOMAIN-CONTAINING PROTEINS; LINKED MENTAL-RETARDATION; PHF8; GENE; METHYLATION; FAMILY; FOLLISTATIN; MUTATIONS; ACTIVIN; BETA;

D O I：

10.1101/gad.1864410

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KDM7 orthologs in zebrafish resulted in developmental brain defects. KDM7 interacts with the follistatin gene locus, and KDM7 depletion in mammalian neuronal cells suppressed follistatin gene transcription in association with increased levels of dimethylated H3K9 and H3K27. Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development.

引用

页码：432 / 437

页数：6

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