Mechanisms of ATP dependent chromatin remodeling

被引:108
作者
Gangaraju, Vamsi K. [1 ]
Bartholomew, Blaine [1 ]
机构
[1] So Illinois Univ, Sch Med, Dept Biochem & Mol Biol, Carbondale, IL 62901 USA
关键词
chromatin remodeling; nucleosome; SWI/SNF; ISWI; CHD; INO80; SWR1; twist diffusion; bulge propagation; nucleosome spacing;
D O I
10.1016/j.mrfmmm.2006.08.015
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The inter-relationship between DNA repair and ATP dependent chromatin remodeling has begun to become very apparent with recent discoveries. ATP dependent remodeling complexes mobilize nucleosomes along DNA, promote the exchange of histones, or completely displace nucleosomes from DNA. These remodeling complexes are often categorized based on the domain organization of their catalytic subunit. The biochemical properties and structural information of several of these remodeling complexes are reviewed. The different models for how these complexes are able to mobilize nucleosomes and alter nucleosome structure are presented incorporating several recent findings. Finally the role of histone tails and their respective modifications in ATP-dependent remodeling are discussed. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 17
页数:15
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