The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

被引：552

作者：

Bakhoum, Samuel F. ^{[1
,2
]}

Cantley, Lewis C. ^{[3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10065 USA

[3] Weill Cornell Med, Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA

来源：

CELL | 2018年 / 174卷 / 06期

关键词：

MEROTELIC KINETOCHORE ORIENTATION; BREAST-CANCER; DNA-DAMAGE; GENOMIC INSTABILITY; EXONUCLEASE TREX1; HUMAN-CELLS; TUMOR; ANEUPLOIDY; EVOLUTION; SENSOR;

D O I：

10.1016/j.cell.2018.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.

引用

页码：1347 / 1360

页数：14

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