Anxioselective anxiolytics: can less be more?

被引：40

作者：

Basile, AS ^{[1
]}

Lippa, AS ^{[1
]}

Skolnick, P ^{[1
]}

机构：

[1] DOV Pharmaceut Inc, Hackensack, NJ 07601 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 500卷 / 1-3期

关键词：

anxiolytic; benzodiazepine; gamma-aminobutyric acid(A);

D O I：

10.1016/j.ejphar.2004.07.043

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Benzodiazepines remain widely used for the treatment of anxiety disorders despite a side-effect profile that includes sedation, myorelaxation, amnesia, and ataxia, and the potential for abuse. gamma-Aminobutyric acid(A) (GABA(A)) receptor partial agonists, subtype-selective agents, and compounds combining both of these features are being developed in an attempt to achieve benzodiazepine-like efficacy without these potentially limiting side effects. This article reviews the nonclinical and clinical studies of "anxioselective" anxiolytics that target GABA(A) receptors and discusses potential mechanisms subserving an anxioselective profile. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：441 / 451

页数：11

共 97 条

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