Retinal vessel diameters and the role of inflammation in cerebrovascular disease

被引：63

作者：

de Jong, Frank Jan

Ikram, M. Kamran

Witteman, Jacqueline C. M.

Hoftnan, Albert

de Jong, Paulus T. V. M.

Breteler, Monique M. B.

机构：

[1] Netherlands Inst Neurosci, KNAW, NL-1105 BA Amsterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[3] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, NL-1105 AZ Amsterdam, Netherlands

来源：

ANNALS OF NEUROLOGY | 2007年 / 61卷 / 05期

关键词：

D O I：

10.1002/ana.21129

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Retinal vessels may provide a way to study the cerebral microcirculation. In particular, larger retinal venular diameters have been associated with cerebrovascular disease. An inflammatory response may underlie this association. In a population-based cohort study among 5,279 participants aged 55 years or older with graded retinal vessel diameters, we observed that greater serum levels of C-reactive protein and fibrinogen and greater lipoprotein-associated phospholipase A, activity were strongly associated with larger venular diameters. Weaker associations were found with arteriolar diameters. Our findings support the hypothesis that larger retinal venular diameters reflect systemic inflammation and suggest that inflammation is involved in cerebrovascular disease.

引用

收藏

页码：491 / 495

页数：5

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